A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia

LM Jenkins, L Wang, H Rosen, S Weintraub - Brain, 2022 - academic.oup.com
Apathy and disinhibition are common and highly distressing neuropsychiatric symptoms
associated with negative outcomes in persons with dementia. This paper is a critical review …

Cognitive and behavioural inhibition deficits in neurodegenerative dementias

R Migliaccio, D Tanguy, A Bouzigues, I Sezer… - Cortex, 2020 - Elsevier
Disinhibition, mainly caused by damage in frontotemporal brain regions, is one of the major
causes of caregiver distress in neurodegenerative dementias. Behavioural inhibition deficits …

Disordered decision making: a cognitive framework for apathy and impulsivity in huntington's disease

LA Morris, C O'Callaghan, C Le Heron - Movement Disorders, 2022 - Wiley Online Library
A caregiver's all‐too‐familiar narrative‐“He doesn't think through what he does, but mostly
he does nothing.” Apathy and impulsivity, debilitating and poorly understood, commonly co …

What do we mean by behavioral disinhibition in frontotemporal dementia?

N Magrath Guimet, BL Miller, RF Allegri… - Frontiers in …, 2021 - frontiersin.org
Behavioral variant frontotemporal dementia, unlike other forms of dementia, is primarily
characterized by changes in behavior, personality, and language, with disinhibition being …

Behavioral variant frontotemporal dementia and social and criminal transgressions

MF Mendez - The Journal of Neuropsychiatry and Clinical …, 2022 - Am Neuropsych Assoc
Objective: Behavioral variant frontotemporal dementia (bvFTD) is associated with social and
criminal transgressions; studies from countries around the world have documented such …

Subjective time in dementia: A critical review

L Liu, A Bulley, M Irish - Brain sciences, 2021 - mdpi.com
The capacity for subjective time in humans encompasses the perception of time's unfolding
from moment to moment, as well as the ability to traverse larger temporal expanses of past …

Face name matching and memory complaints in Parkinson's disease

A Siquier, P Andrés - Frontiers in psychology, 2022 - frontiersin.org
Objective Memory impairment is a hallmark cognitive deficit in Parkinson's disease (PD).
However, it remains unclear which processes underlie this deficit in PD. Also, little is known …

Relationship between elevated impulsivity and cognitive declines in elderly community-dwelling individuals

K Sakurai, H Li, N Inamura, N Masuoka, T Hisatsune - Scientific reports, 2020 - nature.com
Impulse control disorders are recognized as one of the behavioral and psychological
symptoms of dementia (BPSD). Majority of studies on the treatment of BPSD related to …

Altered delay discounting in neurodegeneration: insight into the underlying mechanisms and perspectives for clinical applications

V Godefroy, I Sezer, A Bouzigues… - Neuroscience & …, 2023 - Elsevier
Steeper delay discounting (ie, the extent to which future rewards are perceived as less
valuable than immediate ones) has been proposed as a transdiagnostic process across …

Pharmacological inhibition of PLK2 kinase activity mitigates cognitive decline but aggravates APP pathology in a sex-dependent manner in APP/PS1 mouse model of …

L Martínez-Drudis, M Bérard, D Musiol, S Rivest… - Heliyon, 2024 - cell.com
Converging evidence from clinical and experimental studies suggest the potential
significance of Polo-like kinase 2 (PLK2) in regulating the phosphorylation and toxicity of the …