A staphylococcal capsule-producing enzyme that unfolds via multiple intermediates predominantly exists as the trimers at low concentrations
T Chakraborty, S Polley, N Ray Chaudhuri… - Journal of …, 2024 - Taylor & Francis
CapG, an enzyme expressed by Staphylococcus aureus, catalyzes an epimerization
reaction to synthesize N-acetyl-L-fucosamine, a constituent of capsule involved in …
reaction to synthesize N-acetyl-L-fucosamine, a constituent of capsule involved in …
A conserved arginine residue in a staphylococcal anti-sigma factor is required to preserve its kinase activity, structure, and stability
RsbW, σB, and RsbV, encoded by Staphylococcus aureus and related bacteria, act as an
anti-sigma factor, an sigma factor, and an anti-anti-sigma factor, respectively. The interaction …
anti-sigma factor, an sigma factor, and an anti-anti-sigma factor, respectively. The interaction …
A staphylococcal cyclophilin carries a single domain and unfolds via the formation of an intermediate that preserves cyclosporin A binding activity
S Seal, S Polley, S Sau - Plos one, 2019 - journals.plos.org
Cyclophilin (Cyp), a peptidyl-prolyl cis-trans isomerase (PPIase), acts as a virulence factor in
many bacteria including Staphylococcus aureus. The enzymatic activity of Cyp is inhibited …
many bacteria including Staphylococcus aureus. The enzymatic activity of Cyp is inhibited …
Serine 106 preserves the tertiary structure, function, and stability of a cyclophilin from Staphylococcus aureus
S Seal, N Banerjee, R Mahato, T Kundu… - Journal of …, 2023 - Taylor & Francis
SaCyp, a staphylococcal cyclophilin involved in both protein folding and pathogenesis, has
a Ser residue at position 106 and a Trp residue at position 136. While Ser 106 of SaCyp …
a Ser residue at position 106 and a Trp residue at position 136. While Ser 106 of SaCyp …
Structurally distinct unfolding intermediates formed from a staphylococcal capsule-producing enzyme retained NADPH binding activity
CapF, a capsule-producing enzyme expressed by Staphylococcus aureus, binds NADPH
and exists as a dimer in the aqueous solution. Many other capsule-producing virulent …
and exists as a dimer in the aqueous solution. Many other capsule-producing virulent …
Dimerization ability, denaturation mechanism, and the stability of a staphylococcal phage repressor and its two domains
The lysogenic growth of phage ф11 in Staphylococcus aureus is controlled by a repressor
(CI) that harbors an N-terminal domain (NTD), and a C-terminal domain (CTD). Previously …
(CI) that harbors an N-terminal domain (NTD), and a C-terminal domain (CTD). Previously …
Understanding the structure, stability, and anti-sigma factor-binding thermodynamics of an anti-anti-sigma factor from Staphylococcus aureus
Staphylococcus aureus and many related bacteria encode both anti-sigma factor RsbW and
anti-anti-sigma factor RsbV to control stress response by σB, an alternative sigma factor. Our …
anti-anti-sigma factor RsbV to control stress response by σB, an alternative sigma factor. Our …
Alternative Sigma Factor of Staphylococcus aureus Interacts with the Cognate Antisigma Factor Primarily Using Its Domain 3
σB, an alternative sigma factor, is usually employed to tackle the general stress response in
Staphylococcus aureus and other Gram-positive bacteria. This protein, involved in S. aureus …
Staphylococcus aureus and other Gram-positive bacteria. This protein, involved in S. aureus …