Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
Optimizing survival and the changing landscape of targeted therapy for intermediate and advanced hepatocellular carcinoma: a systematic review
H Lim, R Ramjeesingh, D Liu, VC Tam… - JNCI: Journal of the …, 2021 - academic.oup.com
Background: Systemic therapy for hepatocellular carcinoma (HCC) consisting of the tyrosine
kinase inhibitor sorafenib has remained unchanged for over a decade, although results from …
kinase inhibitor sorafenib has remained unchanged for over a decade, although results from …
GOT2 silencing promotes reprogramming of glutamine metabolism and sensitizes hepatocellular carcinoma to glutaminase inhibitors
Hepatocellular carcinoma (HCC) is one of the primary liver malignancies with a poor
prognosis. Glutamic-oxaloacetic transaminase 2 (GOT2) is a highly tissue-specific gene in …
prognosis. Glutamic-oxaloacetic transaminase 2 (GOT2) is a highly tissue-specific gene in …
The evolution of immune checkpoint inhibitor combinations in advanced hepatocellular carcinoma–A systematic review
Background and objective Since approval of sorafenib in 2008, systemic therapy has been
established as the main treatment option for advanced hepatocellular carcinoma (HCC) …
established as the main treatment option for advanced hepatocellular carcinoma (HCC) …
Melatonin and gastrointestinal cancers: Current evidence based on underlying signaling pathways
Gastrointestinal (GI) cancers, leading causes of cancer-related deaths, have been serious
challenging human diseases up to now. Because of high rates of mortality, late-stage …
challenging human diseases up to now. Because of high rates of mortality, late-stage …
[HTML][HTML] Improved anti-hepatocellular carcinoma effect by enhanced Co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles
C Song, J Zhang, R Wen, Q Li, J Zhou, Z Wu, Y Lv… - Materials Today Bio, 2022 - Elsevier
Effective systemic treatment for hepatocellular carcinoma (HCC) remains urgently needed.
Sorafenib is the first FDA-approved systemic treatment for HCC. However, individual HCC …
Sorafenib is the first FDA-approved systemic treatment for HCC. However, individual HCC …
[HTML][HTML] Bioactive components and mechanisms of poplar propolis in inhibiting proliferation of human hepatocellular carcinoma HepG2 cells
H Liu, J Li, W Yuan, S Hao, M Wang, F Wang… - Biomedicine & …, 2021 - Elsevier
Background The aim of this study was to elucidate the bioactive components and anti-tumor
mechanism of poplar propolis extract obtained from North China (CP) in human …
mechanism of poplar propolis extract obtained from North China (CP) in human …
A disintegrin and metalloproteinase 9 (ADAM9) in advanced hepatocellular carcinoma and their role as a biomarker during hepatocellular carcinoma immunotherapy
S Oh, YJ Park, HJ Lee, J Lee, SH Lee, YS Baek… - Cancers, 2020 - mdpi.com
The chemotherapeutics sorafenib and regorafenib inhibit shedding of MHC class I-related
chain A (MICA) from hepatocellular carcinoma (HCC) cells by suppressing a disintegrin and …
chain A (MICA) from hepatocellular carcinoma (HCC) cells by suppressing a disintegrin and …
Current perspectives on B lymphocytes in the immunobiology of hepatocellular carcinoma
M Qin, D Wang, Y Fang, Z Zheng, X Liu, F Wu… - Frontiers in …, 2021 - frontiersin.org
Immune cells infiltrating tumors are capable of significantly impacting carcinogenesis
through cancer promotion and anticancer responses. There are many aspects of …
through cancer promotion and anticancer responses. There are many aspects of …
[HTML][HTML] Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer
M Suresh, S Menne - World Journal of Gastrointestinal Oncology, 2021 - ncbi.nlm.nih.gov
This review describes woodchucks chronically infected with the woodchuck hepatitis virus
(WHV) as an animal model for hepatocarcinogenesis and treatment of primary liver cancer …
(WHV) as an animal model for hepatocarcinogenesis and treatment of primary liver cancer …