The role of long noncoding RNAs in neurodegenerative diseases

P Wan, W Su, Y Zhuo - Molecular neurobiology, 2017 - Springer
Long noncoding RNAs (lncRNAs) are transcripts with low protein-coding potential but
occupy a large part of transcriptional output. Their roles include regulating gene expression …

Major review: exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology

IF Aboobakar, WM Johnson, WD Stamer… - Experimental eye …, 2017 - Elsevier
Exfoliation syndrome (XFS) is a common age-related disorder that leads to deposition of
extracellular fibrillar material throughout the body. The most recognized disease …

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

T Aung, M Ozaki, MC Lee, U Schlötzer-Schrehardt… - Nature …, 2017 - nature.com
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma
and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A …

Molecular genetics of glaucoma: Subtype and ethnicity considerations

R Zukerman, A Harris, A Verticchio Vercellin, B Siesky… - Genes, 2020 - mdpi.com
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …

Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1

BO Long, NA Li, XX Xu, XX Li, XJ Xu, JY Liu… - … and biophysical research …, 2018 - Elsevier
Prostate cancer is one of the most frequent malignancies affecting men. Long non-coding
RNAs (lncRNAs) are involved in the pathogenesis of prostate cancer. LncRNA LOXL1-AS1 …

Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

MD Drewry, P Challa, JG Kuchtey… - Human molecular …, 2018 - academic.oup.com
Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …

Pseudoexfoliation syndrome and glaucoma: from genes to disease mechanisms

U Schlötzer-Schrehardt, CC Khor - Current Opinion in …, 2021 - journals.lww.com
PEX-associated genes are beginning to reveal relevant biological pathways and processes
involved in disease development. To understand the functional consequences and …

LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating …

L Zhang, H Xie, S Li - Journal of bone and mineral metabolism, 2020 - Springer
Introduction Exploring molecular mechanisms of human bone marrow mesenchymal stem
cells (hBMMSCs) differentiation, a crucial step for bone formation, is a new direction for …

LncRNA LOXL1‐AS1 promotes the proliferation and metastasis of medulloblastoma by activating the PI3K/AKT pathway

R Gao, R Zhang, C Zhang, Y Liang… - Analytical Cellular …, 2018 - Wiley Online Library
Medulloblastoma is the most common malignant brain tumor of childhood, with great
potential to metastasize. However, the mechanisms of how medulloblastoma develops and …

[HTML][HTML] LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population …

N Eliseeva, I Ponomarenko, E Reshetnikov… - Molecular …, 2021 - ncbi.nlm.nih.gov
Purpose This study was aimed to replicate the previously reported associations of the three
LOXL1 gene polymorphisms with exfoliation glaucoma (XFG) and to analyze these genetic …