This review examines advancements in the measurement and imaging of oxidized
cytochrome-c-oxidase (oxCCO) using near-infrared spectroscopy (NIRS) in humans since …

Neonatal care has made significant advances in the last few decades. As a result, mortality
and morbidity in high-risk infants, such as extremely preterm infants or those infants with …

Importance Preterm infants with varying degrees of anemia have different tissue oxygen
saturation responses to red blood cell (RBC) transfusion, and low cerebral saturation may …

Significance Continuous wave near infrared spectroscopy (CW-NIRS) is widely exploited in
clinics to estimate skeletal muscles and brain cortex oxygenation. Spatially resolved …

Infants requiring admission to the neonatal intensive care unit (NICU) are particularly
vulnerable to developing brain injury. The severity of the underlying clinical conditions and …

Oxygen is essential for human life, yet a growing body of preclinical research is
demonstrating that chronic continuous hypoxia can be beneficial in models of mitochondrial …

The present study was designed to test the potential utility of regional cerebral oxygen
saturation (rcSO2) in detecting term infants with brain injury. The study also examined …

There is an increasing interest in approaches that can identify heterogeneity in treatment
effects from randomized clinical trials, extending beyond traditional subgroup analyses …

Objective To use cerebral near-infrared spectroscopy (NIRS) to quantify occult cerebral
hypoxia across respiratory support modes in preterm infants. Study design In this …

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