The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling
events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such …

Branching morphogenesis is the developmental program that builds the ramified epithelial
trees of various organs, including the airways of the lung, the collecting ducts of the kidney …

In sprouting angiogenesis, specialized endothelial tip cells lead the outgrowth of blood-
vessel sprouts towards gradients of vascular endothelial growth factor (VEGF)-A,. VEGF-A is …

Incomplete delivery to the target cells is an obstacle for successful gene therapy
approaches. Here we show unexpected effects of incomplete targeting, by demonstrating …

Alagille syndrome is a human autosomal dominant developmental disorder characterized by
liver, heart, eye, skeletal, craniofacial and kidney abnormalities. Alagille syndrome is caused …

▪ Abstract Many organs including the mammalian lung and vascular system consist of
branched tubular networks that transport essential gases or fluids, but the genetic programs …

Delta-Notch signalling regulates cell-fate choices in a variety of tissues during development.
We report the expression of Delta4 (Dl4) in arterial endothelium during mouse …

Although many studies have focused on blood vessel development and new blood vessel
formation associated with disease processes, the question of how endothelial cells (ECs) …

Notch proteins function as receptors for membrane-bound ligands (Jagged and Delta-like) to
regulate cell-fate determination. We have investigated the role of Notch signaling in …

Many organs are composed of tubular networks that arise by branching morphogenesis in
which cells bud from an epithelium and organize into a tube,,. Fibroblast growth factors …