An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect
S Kumar, JM Oh, P Prabhakaran, A Awasti, H Kim… - Scientific Reports, 2024 - nature.com
Sixteen isatin-based hydrazone derivatives (IS1–IS16) were synthesized and assessed for
their ability to inhibit monoamine oxidases (MAOs). All the molecules showed improved …
their ability to inhibit monoamine oxidases (MAOs). All the molecules showed improved …
New Insights into Butyrylcholinesterase: Pharmaceutical Applications, Selective Inhibitors and Multitarget-Directed Ligands
T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
Development of a new class of monoamine oxidase-B inhibitors by fine-tuning the halogens on the acylhydrazones
J Jayan, J Lee, S Kumar, A Manoharan… - ACS …, 2023 - ACS Publications
A total of 14 acyl hydrazine derivatives (ACH1–ACH14) were developed and examined for
their ability to block monoamine oxidase (MAO). Thirteen analogues showed stronger …
their ability to block monoamine oxidase (MAO). Thirteen analogues showed stronger …
Novel coumarin benzamides as potent and reversible monoamine oxidase-B inhibitors: Design, synthesis, and neuroprotective effects
AK El-Damasy, JM Oh, HJ Kim, SK Mun… - Bioorganic …, 2024 - Elsevier
A series of new 6-amidocoumarin derivatives, 3a–j, was synthesized and evaluated for their
inhibitory activity against monoamine oxidase (MAO) and cholinesterase. All compounds …
inhibitory activity against monoamine oxidase (MAO) and cholinesterase. All compounds …
An efficient method to access spiro pseudoindoxyl ketones: evaluation of indoxyl and their N-benzylated derivatives for inhibition of the activity of monoamine oxidases
A simple, metal-free approach was developed to obtain novel pseudoindoxyl derivatives.
The reaction was mediated by tBuOK on tetrahydrocarbazole 8 in dimethyl sulfoxide …
The reaction was mediated by tBuOK on tetrahydrocarbazole 8 in dimethyl sulfoxide …
From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders
J Wu, H Zhang, Y Wang, G Yin, Q Li, L Zhuo… - Frontiers in …, 2022 - frontiersin.org
A novel class of benzyl-free and benzyl-substituted carbamylated tryptamine derivatives
(CDTs) was designed and synthesized to serve as effective building blocks for the …
(CDTs) was designed and synthesized to serve as effective building blocks for the …
Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular …
JM Oh, S Kumar, ST Sudevan, OM Hendawy… - … Biology and Chemistry, 2023 - Elsevier
Oximes are the promising structural scaffold for inhibiting monoamine oxidase (MAO)-B.
Eight chalcone-based oxime derivatives were synthesized by microwave-assisted …
Eight chalcone-based oxime derivatives were synthesized by microwave-assisted …
Inhibition of monoamine oxidases by benzimidazole chalcone derivatives
A Krishna, J Lee, S Kumar, ST Sudevan… - Applied Biological …, 2023 - Springer
Ten benzimidazole chalcone derivatives were synthesized, and their monoamine oxidase
(MAO) inhibitory activity was evaluated. Most compounds showed higher inhibitory activity …
(MAO) inhibitory activity was evaluated. Most compounds showed higher inhibitory activity …
Recent advances in the natural product analogues for the treatment of neurodegenerative diseases
J Zhang, P Jiang, S Wang, M Li, Z Hao, W Guan… - Bioorganic …, 2024 - Elsevier
Neurodegenerative diseases (NDs) represent a hallmark of numerous incapacitating and
untreatable conditions, the incidence of which is escalating swiftly, exemplified by …
untreatable conditions, the incidence of which is escalating swiftly, exemplified by …