Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Proteins perform most cellular functions in macromolecular complexes. The same protein
often participates in different complexes to exhibit diverse functionality. Current ensemble …

For over 150 years Australia has exported bulk, undifferentiated, commodities such as wool,
wheat, meat and sugar to the UK and more recently to Japan, Korea, and the Middle East. It …

G protein-coupled receptors (GPCRs) mediate cellular responses to a wide variety of
extracellular stimuli. GPCR dimerization may expand signaling diversity and tune …

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+
recycling in organs including the heart, brain, and gut. Loss of function is relatively common …

The light responses of rod and cone photoreceptors have been studied
electrophysiologically for decades, largely with ex vivo approaches that disrupt the …

This paper is the outcome of the fourth UC Davis Systems Approach to Understanding
Cardiac Excitation–Contraction Coupling and Arrhythmias Symposium, a biannual event …