Molecular mechanisms for enhanced DNA vaccine immunogenicity

L Li, N Petrovsky - Expert review of vaccines, 2016 - Taylor & Francis
In the two decades since their initial discovery, DNA vaccines technologies have come a
long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still …

The future of human DNA vaccines

L Li, F Saade, N Petrovsky - Journal of biotechnology, 2012 - Elsevier
DNA vaccines have evolved greatly over the last 20 years since their invention, but have yet
to become a competitive alternative to conventional protein or carbohydrate based human …

Immunoinformatics-guided design of an epitope-based vaccine against severe acute respiratory syndrome coronavirus 2 spike glycoprotein

A Rakib, SA Sami, NJ Mimi, MM Chowdhury… - Computers in biology …, 2020 - Elsevier
Aims With a large number of fatalities, coronavirus disease-2019 (COVID-19) has greatly
affected human health worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Current challenges in vaccinology

RB Kennedy, IG Ovsyannikova, P Palese… - Frontiers in …, 2020 - frontiersin.org
The development of vaccines, which prime the immune system to respond to future
infections, has led to global declines in morbidity and mortality from dreadful infectious …

[HTML][HTML] Vaccines: from empirical development to rational design

C Rueckert, CA Guzmán - PLoS pathogens, 2012 - journals.plos.org
Infectious diseases are responsible for an overwhelming number of deaths worldwide and
their clinical management is often hampered by the emergence of multi-drug-resistant …

Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach

ND Lambert, IG Ovsyannikova, VS Pankratz… - Expert review of …, 2012 - Taylor & Francis
Annual vaccination against seasonal influenza is recommended to decrease disease-
related mortality and morbidity. However, one population that responds suboptimally to …

Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century

GA Poland, RB Kennedy, BA McKinney… - Seminars in …, 2013 - Elsevier
Vaccines, like drugs and medical procedures, are increasingly amenable to individualization
or personalization, often based on novel data resulting from high throughput “omics” …

[HTML][HTML] Vaccines meet big data: State-of-the-Art and future prospects. From the classical 3Is (“Isolate–Inactivate–Inject”) vaccinology 1.0 to vaccinology 3.0 …

NL Bragazzi, V Gianfredi, M Villarini… - Frontiers in public …, 2018 - frontiersin.org
Vaccines are public health interventions aimed at preventing infections-related mortality,
morbidity, and disability. While vaccines have been successfully designed for those …

Vaccine discovery and translation of new vaccine technology

R Rappuoli, S Black, PH Lambert - The Lancet, 2011 - thelancet.com
An unprecedented increase in new vaccine development has occurred over the past three
decades. This activity has resulted in vaccines that protect against an increased range of …

The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches

IH Haralambieva, IG Ovsyannikova… - Expert review of …, 2013 - Taylor & Francis
The live-attenuated measles vaccine is effective, but measles outbreaks still occur in
vaccinated populations. This warrants elucidation of the determinants of measles vaccine …