[HTML][HTML] Physiological functions of the cholinergic system in immune cells

T Fujii, M Mashimo, Y Moriwaki, H Misawa… - Journal of …, 2017 - Elsevier
T and B cells, macrophages and dendritic cells (DCs) all express most of the components
necessary for a functional cholinergic system. This includes choline acetyltransferase …

Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function

K Kawashima, T Fujii, Y Moriwaki, H Misawa - Life sciences, 2012 - Elsevier
Lymphocytes express both muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs
and nAChRs, respectively), and stimulation of mAChRs and nAChRs produces various …

Regulation of immune functions by non-neuronal acetylcholine (ACh) via muscarinic and nicotinic ACh receptors

M Mashimo, Y Moriwaki, H Misawa… - International journal of …, 2021 - mdpi.com
Acetylcholine (ACh) is the classical neurotransmitter in the cholinergic nervous system.
However, ACh is now known to regulate various immune cell functions. In fact, T cells, B …

[HTML][HTML] Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs

K Kawashima, T Fujii, Y Moriwaki, H Misawa… - International …, 2015 - Elsevier
Abstract In 1929, Dale and Dudley described the first reported natural occurrence of
acetylcholine (ACh) in an animal's body. They identified this ACh in the spleens of horses …

The V‐ATPase proteolipid cylinder promotes the lipid‐mixing stage of SNARE‐dependent fusion of yeast vacuoles

B Strasser, J Iwaszkiewicz, O Michielin… - The EMBO journal, 2011 - embopress.org
The V‐ATPase V0 sector associates with the peripheral V1 sector to form a proton pump. V0
alone has an additional function, facilitating membrane fusion in the endocytic and late …

Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function

K Kawashima, T Fujii, Y Moriwaki… - Annals of the New …, 2012 - Wiley Online Library
Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine (ACh)
receptors (mAChRs and nAChRs, respectively), and agonist stimulation of these AChRs …

Regulatory mechanisms of acetylcholine synthesis and release by T cells

T Fujii, Y Takada-Takatori, K Kawashima - Life sciences, 2012 - Elsevier
AIMS: Muscarinic and nicotinic acetylcholine (ACh) receptors are expressed in immune
cells. ACh synthesized by choline acetyltransferase (ChAT) and released in T cells binds to …

Ultrafast and slow cholinergic transmission. Different involvement of acetylcholinesterase molecular forms

Y Dunant, V Gisiger - Molecules, 2017 - mdpi.com
Acetylcholine (ACh), an ubiquitous mediator substance broadly expressed in nature, acts as
neurotransmitter in cholinergic synapses, generating specific communications with different …

Mediatophore regulates acetylcholine release from T cells

T Fujii, Y Takada-Takatori, K Horiguchi… - Journal of …, 2012 - Elsevier
Immunological stimulation of T cells by phytohemagglutinin (PHA) enhances the synthesis
and release of acetylcholine (ACh), suggesting a role for the lymphocytic cholinergic system …

Contributions of Non-Neuronal Cholinergic Systems to the Regulation of Immune Cell Function, Highlighting the Role of α7 Nicotinic Acetylcholine Receptors

K Kawashima, M Mashimo, A Nomura… - International Journal of …, 2024 - mdpi.com
Loewi's discovery of acetylcholine (ACh) release from the frog vagus nerve and the
discovery by Dale and Dudley of ACh in ox spleen led to the demonstration of chemical …