Hypoxia is a condition always present in tumor environment owing to the fast growth of
tumor cells not supported by adequate blood supply. There is increasing evidence that …

Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to
the mechanisms controlling cellular responses under such stress stimuli, are the …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

Mammals have developed evolutionarily conserved programs of transcriptional response to
hypoxia and inflammation. These stimuli commonly occur together in vivo and there is …

Tumor growth creates a hypoxic microenvironment, which promotes angiogenesis and
aggressive tumor growth and invasion. HIF1α is a central molecule involved in mediating …

Poor prognosis of head and neck squamous cell carcinomas (HNSCCs) results from
resistance to chemotherapy and radiotherapy. To uncover the drivers of HNSCC resistance …

Neuroblastoma is a pediatric cancer characterized by variable outcomes ranging from
spontaneous regression to life-threatening progression. High-risk neuroblastoma patients …

Purpose Ten eleven translocation (TET) enzyme activity is essential for active DNA
demethylation in biological processes, and their altered expression has been observed in …

The intestine is supported by a complex vascular system that undergoes dynamic and
transient daily shifts in blood perfusion, depending on the metabolic state. Moreover, the …

Luminal A breast cancer, constituting 70% of breast cancer cases, presents a challenge due
to the development of resistance and recurrence caused by breast cancer stem cells …