The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …

STAT3 gain-of-function (GOF) syndrome is a multi-organ primary immune regulatory
disorder characterized by early onset autoimmunity. Patients present early in life, most …

The essential role of B cells is to produce protective immunoglobulins (Ig) that recognize,
neutralize, and clear invading pathogens. This results from the integration of signals …

Primary immune regulatory disorders (PIRDs) are inborn errors of immunity caused by a loss
in the regulatory mechanism of the inflammatory or immune response, leading to impaired …

Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …

Abstract Craniosynostosis, hyper-IgE syndrome, Job's syndrome Available treatments
include immunoglobulin substitution and antimicrobial prophylaxis, and also HSCT …

The increasing use of molecular diagnostics has led to rapid expansion of the genotypic and
phenotypic landscape of inborn errors of immunity (IEIs). Like cancer, IEIs are proving to be …

Background GATA2 deficiency is an inborn error of immunity (IEI) characterized by infectious
susceptibility and increased risk of myelodysplasia leading to acute myeloid leukaemia …

3. Nakagawa H, Nemoto O, Igarashi A, et al. Delgocitinib ointment, a topical Janus kinase
inhibitor, in adult patients with moderate to severe atopic dermatitis: a phase 3, randomized …

Abstract STAT3 Gain-of-Function (GOF) syndrome characterized by early onset
autoimmunity and primary immune regulatory disorder, the immunological mechanisms …