The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
Giving AXL the axe: targeting AXL in human malignancy
The receptor tyrosine kinase AXL, activated by a complex interaction between its ligand
growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular …
growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular …
Mir-34: a new weapon against cancer?
The microRNA (miRNA)-34a is a key regulator of tumor suppression. It controls the
expression of a plethora of target proteins involved in cell cycle, differentiation and …
expression of a plethora of target proteins involved in cell cycle, differentiation and …
EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer
E Tulchinsky, O Demidov, M Kriajevska… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Epithelial mesenchymal transition (EMT) is a reversible developmental genetic programme
of transdifferentiation of polarised epithelial cells to mesenchymal cells. In cancer, EMT is an …
of transdifferentiation of polarised epithelial cells to mesenchymal cells. In cancer, EMT is an …
Macrophage‐mediated tumor cell phagocytosis: opportunity for nanomedicine intervention
Macrophages are one of the most abundant non‐malignant cells in the tumor
microenvironment, playing critical roles in mediating tumor immunity. As important innate …
microenvironment, playing critical roles in mediating tumor immunity. As important innate …
The p53/miR-34 axis in development and disease
M Rokavec, H Li, L Jiang… - Journal of molecular cell …, 2014 - academic.oup.com
The tumor suppressor p53 is one of the most frequently mutated genes in human cancers.
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …
[HTML][HTML] AXL kinase as a novel target for cancer therapy
X Wu, X Liu, S Koul, CY Lee, Z Zhang, B Halmos - Oncotarget, 2014 - ncbi.nlm.nih.gov
The AXL receptor tyrosine kinase and its major ligand, GAS6 have been demonstrated to be
overexpressed and activated in many human cancers (such as lung, breast, and pancreatic …
overexpressed and activated in many human cancers (such as lung, breast, and pancreatic …
Breast cancer stem cells, EMT and therapeutic targets
S Kotiyal, S Bhattacharya - Biochemical and biophysical research …, 2014 - Elsevier
A small heterogeneous population of breast cancer cells acts as seeds to induce new tumor
growth. These seeds or breast cancer stem cells (BCSCs) exhibit great phenotypical …
growth. These seeds or breast cancer stem cells (BCSCs) exhibit great phenotypical …
MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1
S Yang, Y Li, J Gao, T Zhang, S Li, A Luo, H Chen… - Oncogene, 2013 - nature.com
MicroRNAs have key roles in tumor metastasis. Here, we describe the regulation and
function of miR-34a and miR-34c (miR-34a/c) in breast cancer metastasis. Expression …
function of miR-34a and miR-34c (miR-34a/c) in breast cancer metastasis. Expression …
The receptor tyrosine kinase AXL in cancer progression
EB Rankin, AJ Giaccia - Cancers, 2016 - mdpi.com
The AXL receptor tyrosine kinase (AXL) has emerged as a promising therapeutic target for
cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor …
cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor …