Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …

Endometrial cancer is a common gynaecological cancer with increasing incidence and
mortality. In the last decade, endometrial cancer genome-wide association studies (GWAS) …

Multimorbidity, the coexistence of multiple health conditions in an individual, has emerged
as one of the greatest challenges facing health services, and this crisis is partly driven by the …

The process of identifying suitable genome-wide association (GWA) studies and formatting
the data to calculate multiple polygenic risk scores on a single genome can be laborious …

Background Early-onset cancer (diagnosed under age 50) generally manifests as an
aggressive disease phenotype. The association between healthy lifestyle and early-onset …

Understanding the racial specificities of diseases—such as adult diffuse glioma, the most
common primary malignant tumor of the central nervous system—is a critical step toward …

Approximately 10% of malignancies occur in carriers of germline mutations predisposing to
cancer. A high risk of developing lymphomas has been noted in many primary …

Genetic variations are associated with individual susceptibility to gastric cancer. Recently,
polygenic risk score (PRS) models have been established based on genetic variants to …

Abstract Purpose Single-nucleotide variations (SNVs)(formerly single-nucleotide
polymorphism [SNV]) influence genetic predisposition to endometrial cancer. We …

Background Polygenic risk scores (PRS) aggregate the contribution of many risk variants to
provide a personalized genetic susceptibility profile. Since sample sizes of glioma genome …