Gastric cancer is globally the fourth leading cause of cancer-related deaths. Patients with
diffuse-type gastric cancer (DGC) particularly have a poor prognosis that only marginally …

Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome
characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer …

There are three major hereditable syndromes that affect primarily the stomach: hereditary
diffuse gastric cancer (HDGC), gastric adenocarcinoma and proximal polyposis of the …

Background Signet ring cell carcinoma (SRCC) is a particular histologic variant of gastric
cancer (GC). However, the critical factor related to the aggressive characteristics of SRCC …

Signet ring cell carcinoma (SRCC) of the stomach is a rare type of cancer with a slowly rising
incidence. It tends to be more difficult to detect by pathologists, mainly due to its cellular …

Background: The prevalence of Helicobacter pylori infection and chronic atrophic gastritis is
decreasing in Japan, which has led to a decline in the incidence of gastric cancer. However …

Simple Summary Inactivating mutations in the CDH1 gene cause the cancer syndrome
hereditary diffuse gastric cancer and are also frequent in sporadic diffuse gastric and lobular …

Gastric cancer is ranked fifth among the most commonly diagnosed cancers, and is the
fourth leading cause of cancer-related deaths worldwide. The majority of gastric cancers are …

Loss of the cell–cell adhesion protein E‐cadherin underlies the development of diffuse‐type
gastric cancer (DGC), which is characterized by the gradual accumulation of tumor cells …

Stage IA gastric adenocarcinoma, characterized by foci of intramucosal signet ring cells
(SRC), is found in nearly all asymptomatic patients with germline pathogenic CDH1 variants …