Mobile cognition: imaging the human brain in the 'real world'

M Stangl, SL Maoz, N Suthana - Nature Reviews Neuroscience, 2023 - nature.com
Cognitive neuroscience studies in humans have enabled decades of impactful discoveries
but have primarily been limited to recording the brain activity of immobile participants in a …

The future of brain circuit-targeted therapeutics

SH Siddiqi, S Khosravani, JD Rolston… - …, 2024 - nature.com
The principle of targeting brain circuits has drawn increasing attention with the growth of
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …

Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion

YH Nho, CE Rolle, U Topalovic, RS Shivacharan… - Neuron, 2024 - cell.com
Treatment-resistant obsessive-compulsive disorder (OCD) occurs in approximately one-third
of OCD patients. Obsessions may fluctuate over time but often occur or worsen in the …

A comprehensive review of emerging trends and innovative therapies in epilepsy management

S Ghosh, JK Sinha, S Ghosh, H Sharma, R Bhaskar… - Brain Sciences, 2023 - mdpi.com
Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial
number of patients facing drug-resistant epilepsy. This comprehensive review explores …

An orexigenic subnetwork within the human hippocampus

DAN Barbosa, S Gattas, JS Salgado, FM Kuijper… - Nature, 2023 - nature.com
Only recently have more specific circuit-probing techniques become available to inform
previous reports implicating the rodent hippocampus in orexigenic appetitive processing …

A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger

X Cui, Q Tong, H Xu, C Xie, L Xiao - Progress in Neurobiology, 2023 - Elsevier
Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …

Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders

D Chen, Z Zhao, J Shi, S Li, X Xu, Z Wu, Y Tang… - Translational …, 2024 - nature.com
Substance use disorders (SUDs) imposes profound physical, psychological, and
socioeconomic burdens on individuals, families, communities, and society as a whole, but …

The role of the endocannabinoid system in binge eating disorder

R Bourdy, K Befort - International Journal of Molecular Sciences, 2023 - mdpi.com
Eating disorders are multifactorial disorders that involve maladaptive feeding behaviors.
Binge eating disorder (BED), the most prevalent of these in both men and women, is …

Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet

HF Hounchonou, H Tang, R Paulat, A Kühn… - Scientific Reports, 2023 - nature.com
Obesity is an enormous health problem, and many patients do not respond to any of the
available therapies. Deep brain stimulation (DBS) is currently investigated as a potential …

No time to lose: the current state of research in rapid-acting psychotherapeutics

JA Gordon, ND Volkow, GF Koob - Neuropsychopharmacology, 2024 - nature.com
The vast majority of treatments for psychiatric and substance use disorders take weeks to
work. Notable exceptions to this rule exist, with some treatments such as intravenous …