Abstract T-cell receptor (TCR)-based adoptive therapy employs genetically modified
lymphocytes that are directed against specific tumor markers. This therapeutic modality …

PRAME or PReferentially expressed Antigen in Melanoma is a testis-selective cancer testis
antigen (CTA) with restricted expression in somatic tissues and re-expression in various …

We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657
pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally …

Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis
antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and …

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the
lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma …

Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma
and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through …

Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity.
Identification of new therapeutic targets would be instrumental in improving patient …

Dynamic network biomarkers (DNB) can identify the critical state or tipping point of a
disease, thereby predicting rather than diagnosing the disease. However, it is difficult to …

The preferentially expressed antigen of melanoma (PRAME), a tumor-associated antigen, is
considered a prognostic marker for various human malignancies. The prognostic …