Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Calreticulin (CRT) is a pleiotropic and highly conserved molecule that is mainly localized in
the endoplasmic reticulum. Recently, CRT has gained special interest for its functions …

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to
progressive bone marrow (BM) fibrosis. Although the cellular mutations involved in the …

Background The calreticulin (CALR) exon 9 mutations that are identified in 20% of patients
with Philadelphia chromosome negative chronic myeloproliferative neoplasms (MPN) …

Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an
endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by …

Two major chaperones, calreticulin (CRT) and binding immunoglobulin protein (GRP78/BiP)
dependent on their location, have immunoregulatory or anti‐inflammatory functions …

The myeloproliferative neoplasms are associated with chronic kidney disease but whether
clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney …

Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPN) are
neoplastic diseases of the hematopoietic stem cells in the bone marrow. MPN are …

An endoplasmic reticulum resident protein, calreticulin (CRT), participates in many cellular
processes. CRT is a tumor‐associated antigen with an important role in antitumor immunity …

Calreticulin (CALR), an endoplasmic reticulum–associated chaperone, is frequently mutated
in myeloproliferative neoplasms (MPNs). Mutated CALR promotes downstream JAK2/STAT5 …