As sites of cellular respiration and energy production, mitochondria play a central role in cell
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …

Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-
directional differentiation, and paracrine and immune regulation. As a result of these …

Mesenchymal stem cells (MSCs) are characterized to have the capacity of self-renewal and
the potential to differentiate into mesoderm, ectoderm-like and endoderm-like cells. MSCs …

Various stem cells gradually turned to be critical players in tissue engineering and
regenerative medicine therapies. Current evidence has demonstrated that in addition to …

The mechanistic target of rapamycin, mTOR, controls cell metabolism in response to growth
signals and stress stimuli. The cellular functions of mTOR are mediated by two distinct …

Background Diabetes is a disease affecting over 500 million people globally due to insulin
insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet …

Metabolic reprogramming of cancer is now considered a hallmark of many malignant
tumors, including breast cancer, which remains the most commonly diagnosed cancer in …

Background Human mitochondrial DNA mutations are associated with common to rare
mitochondrial disorders, which are multisystemic with complex clinical pathologies. The …

BACKGROUND Human pluripotent stem cell (hPSC) lines are known to have a bias in their
differentiation. This gives individual cell lines a propensity to preferentially differentiate …

Mitochondrial function following rotator cuff tendon injury (RCI) influences the tendon
healing. We examined the mitochondrial morphology and function under hypoxia in the …