A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau
Y Gao, Y Wang, H Lei, Z Xu, S Li, H Yu, J Xie… - Translational …, 2023 - Springer
Background Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark
of Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal tau …
of Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal tau …
Pyridazinones containing the (4-methoxyphenyl) piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation
Alzheimer's disease is a progressive and fatal neurodegenerative disease affecting the
elderly population accompanied by a decrease in cholinergic transmission, impairing …
elderly population accompanied by a decrease in cholinergic transmission, impairing …
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications
NV Bhilare, R Shedge, PM Tambe, A More - Medicinal Chemistry …, 2024 - Springer
The 2021 statistics from the International Diabetes Federation reveals that approximately
537 million adults between the ages of 20 and 79 are currently coping with diabetes …
537 million adults between the ages of 20 and 79 are currently coping with diabetes …
Advancements in increasing efficiency of Hydrogen Sulfide in therapeutics: Strategies for targeted delivery as prodrugs
Hydrogen sulfide (H2S) has emerged as a potent therapeutic agent with diverse
physiological functions, including vasodilation, anti-inflammation, and cytoprotection …
physiological functions, including vasodilation, anti-inflammation, and cytoprotection …
Synthesis, molecular docking and ADME-TOX studies of new tacrine analogs as promising for Alzheimer's disease therapy
The modification of drug delivery routes can be used as a promising strategy to improve the
therapeutic profile of various drug agents. Herein, the synthesis and molecular modeling of a …
therapeutic profile of various drug agents. Herein, the synthesis and molecular modeling of a …
Riluzole and its prodrugs for the treatment of Alzheimer's disease
RA Al-Horani - Pharmaceutical Patent Analyst, 2023 - Taylor & Francis
Current medications for Alzheimer's disease help manage symptoms and behavioral
problems. Nevertheless, they do not slow the progression of cognitive decline or dementia …
problems. Nevertheless, they do not slow the progression of cognitive decline or dementia …
Olfactory threshold test as a quick screening tool for cognitive impairment: analysis of two independent cohorts
Y Gao, Y Liu, Y Zhang, Y Wang… - Journal of …, 2023 - content.iospress.com
Background: Olfactory dysfunction appears prior to cognitive decline, and thus it has been
suggested to be an early predictor of Alzheimer's disease. However, it is currently not known …
suggested to be an early predictor of Alzheimer's disease. However, it is currently not known …
smProdrugs: A repository of small molecule prodrugs
In modern drug discovery and development, the prodrug approach has become a crucial
strategy for enhancing the pharmacokinetic profiles of drugs. A prodrug is a chemical …
strategy for enhancing the pharmacokinetic profiles of drugs. A prodrug is a chemical …
Prodrugs for neurodegenerative diseases
Neurodegenerative diseases affecting the central nervous system are a heterogeneous
group of neurological disorders often characterized, among others, by motor, speech …
group of neurological disorders often characterized, among others, by motor, speech …
Prodrug approaches for delivering CNS active agents
N Sharma, DD Das, V Chawla, PA Chawla… - Novel Drug Delivery …, 2025 - Elsevier
Prodrugs are bio-convertible with reversible nature, this drug compounds that require an
enzymatic and/or chemical change in order to release the drug's active part, which then …
enzymatic and/or chemical change in order to release the drug's active part, which then …