Acinetobacter baumannii: An Ancient Commensal with Weapons of a Pathogen

M Sarshar, P Behzadi, D Scribano, AT Palamara… - Pathogens, 2021 - mdpi.com
Acinetobacter baumannii is regarded as a life-threatening pathogen associated with
community-acquired and nosocomial infections, mainly pneumonia. The rise in the number …

The role of reactive species on innate immunity

CMC Andrés, JM Pérez de la Lastra, CA Juan, FJ Plou… - Vaccines, 2022 - mdpi.com
This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

How microbes defend themselves from incoming hydrogen peroxide

A Sen, JA Imlay - Frontiers in immunology, 2021 - frontiersin.org
Microbes rely upon iron as a cofactor for many enzymes in their central metabolic processes.
The reactive oxygen species (ROS) superoxide and hydrogen peroxide react rapidly with …

Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence

JR Sheldon, EP Skaar - PLoS pathogens, 2020 - journals.plos.org
Acinetobacter baumannii is an emerging pathogen that poses a global health threat due to a
lack of therapeutic options for treating drug-resistant strains. In addition to acquiring …

Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance

A Tikhomirova, MM Rahman, SP Kidd, RL Ferrero… - Trends in …, 2024 - cell.com
Reactive oxygen species (ROS), including the superoxide radical anion (O 2•–), hydrogen
peroxide (H 2 O 2), and the hydroxyl radical (• HO), are inherent components of bacterial …

Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment

S Monem, B Furmanek-Blaszk, A Łupkowska… - International Journal of …, 2020 - mdpi.com
Acinetobacter baumannii is considered one of the most persistent pathogens responsible for
nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high …

[HTML][HTML] The intracellular life of Acinetobacter baumannii

A Maure, E Robino, C Van der Henst - Trends in Microbiology, 2023 - cell.com
Acinetobacter baumannii is a Gram-negative opportunistic bacterium responsible for
nosocomial and community-acquired infections. This pathogen is globally disseminated and …

[HTML][HTML] Bacterial hydrophilins promote pathogen desiccation tolerance

ER Green, JN Fakhoury, AJ Monteith, H Pi… - Cell host & …, 2022 - cell.com
Acinetobacter baumannii is a leading cause of hospital-acquired infections, where
outbreaks are driven by its ability to persist on surfaces in a desiccated state. Here, we show …

DksA is a conserved master regulator of stress response in Acinetobacter baumannii

RP Maharjan, GJ Sullivan, FG Adams… - Nucleic acids …, 2023 - academic.oup.com
Coordination of bacterial stress response mechanisms is critical for long-term survival in
harsh environments for successful host infection. The general and specific stress responses …

[HTML][HTML] Developing new therapeutic approaches for treating infections caused by multi-drug resistant Acinetobacter baumannii: Acinetobacter baumannii therapeutics

P Gallagher, S Baker - Journal of Infection, 2020 - Elsevier
Antimicrobial resistance (AMR) represents a major challenge to global health. This problem
is most apparent in healthcare facilities, with a comparatively small number of pathogens …