Approximately 95 percent of malignant tumors arising in the testis are germ-cell tumors, a
term that indicates their origin in primordial germ cells. Germ-cell tumors also occasionally …

Publisher Summary This chapter focuses on the importance of stem cell factor (SCF) and the
stem cell factor receptor (SCFR) in hematopoiesis and other complex developmental …

Adult male germ cell tumors (GCTs) comprise distinct groups: seminomas and
nonseminomas, which include pluripotent embryonal carcinomas as well as other histologic …

Fragile X mental retardation syndrome, the most common cause of hereditary mental
retardation, is directly associated with the FMR1 gene at Xq27. 3. FMR1 encodes an RNA …

Carcinoma in situ of the testis (CIS) is the uniform precursor of testicular germ‐cell tumours.
Morphologically, CIS consists of large, intratubular, gonocyte‐like cells with large nuclei and …

Publisher Summary The development and progression of cancer is associated with the
alterations of genes that control growth and differentiation. The accumulation of genetic …

We have reported previously that about 15% of anaplastic astrocytomas and glioblastomas
show amplification and overexpression of one or more genes from chromosomal segment …

Carcinoma‐in‐situ of the testis (CIS) is the precursor of invasive germ cell tumours. It is
believed that CIS cells may originate from early fetal gonocytes. Recently, the proto …

Abstract Background Germ cell tumours (GCTs) are the most common solid malignancies in
young men. Although high cure rates can be achieved, metastases, resistance to cisplatin …

Human male germ cell tumors (GCTs) arise in the spermatocytic lineage, and subsets
display embryonal-like differentiation. Virtually all GCTs exhibit multiple copies of the short …