In an attempt to find the biorational pesticides, 20 novel chalcone derivatives containing a
piperazine fragment were designed and synthesized. Their fungicidal activities and …

This research emphasizes a new modeling approach by Box Behnken Design in Response
Surface Methodology (RSM) for the optimization of chalcones yield based to the elaborated …

Two β-carboline compounds, 8i and 6d, demonstrated in vitro antileishmanial activity
against Leishmania (L.) amazonensis promastigotes similar to that of miltefosine (MIL) …

The production of a variety of chalcones was brought about as a result of the condensation
of substituted acetophenones with ferrocene aldehyde (I-III). The different Chalcones (I-III) …

The isoxazole core has been identified as an essential privileged structure in discovering
new and potent leishmanicidal agents. Thus, the present study reports the in vitro activity of …

For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for
Chagas disease. However, these drugs present limited effectiveness during the chronic …

Novel chalcone-like compounds, LQFM332 (4), LQFM333 (5), and LQFM341 (6), were
synthesized and their activity against Leishmania (L.) amazonensis was evaluated and …

Bacterial infections pose a significant threat to human health, constituting a major challenge
for healthcare systems. Antibiotic resistance is particularly concerning in the context of …

Electron paramagnetic resonance (EPR) spectroscopy of spin labels was used to study the
interactions of amphotericin B (AmB) with the plasma membrane of Leishmania …

hydroxy-2-nonenal (HNE) is a reactive aldehyde produced by cells under conditions of
oxidative stress, which has been shown to react with proteins and …