Cell proliferation and directed cell movement are key events in several normal processes
including embryogenesis and development, responses to injury such as wound repair, and …

Realization that the transforming oncogenes (v-onc) of the acutely oncogenic retroviruses
are homologous to cellular genes (and were probably derived from them) brought several …

Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug
resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied …

Background: Clinical response to chemotherapy for ovarian cancer is frequently
compromised by the development of drug-resistant disease. The underlying molecular …

Human sequences related to the transforming gene (v-myc) of avian myelocytomatosis virus
(MC29) are represented by at least one gene and several related sequences that may …

The consistent appearance of specific chromosomal translocations in human Burkitt
lymphomas and murine plasmacytomas has suggested that these translocations might play …

Exposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that
exhibited increasing degrees of drug resistance, which were closely correlated with increase …

The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast
Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking …

For many cancers, there is a real need for more effective therapies. Although many drugs
show promising results in vitro, most fail to translate into an in vivo model system, and only∼ …

Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations
involving tubulin. We report two paclitaxel-resistant sublines derived from 1A9 human …