Gβγ subunits mediate many different signaling processes in various compartments of the
cell, including the nucleus. To gain insight into the functions of nuclear Gβγ signaling, we …

Abstract The Polycomb-group protein, Ezh2, is required for epigenetic gene silencing in the
adult heart by unknown mechanism. We investigated the role of Ezh2 and non-coding RNAs …

Chromatin immunoprecipitation, commonly referred to as ChIP, is a powerful technique for
the evaluation of in vivo interactions of proteins with specific regions of genomic DNA …

Pathological cardiac hypertrophy is driven by neurohormonal activation of specific G protein-
coupled receptors (GPCRs) in cardiomyocytes and is accompanied by large-scale changes …

Aims The aim of our study was to set up a simple and reliable isolation method of living
ventricular cardiomyocytes (vCMs) for molecular and biological studies. Methods and results …

Epigenetic modulations are pivotal in heart disease progression, yet the specific influence of
epigenetic alterations on transcription initiation and elongation in heart failure (HF) is poorly …

目的探讨体外转染细胞周期素A2 (Cyclin A2) 基因对原代大鼠心肌细胞增殖的影响,
为心脏再生提供细胞学依据. 方法SD 乳鼠12 只, 分离, 培养, 鉴定原代乳鼠心肌细胞并分为3 组 …

SUMMARY Gβγ subunits are involved in an array of distinct signalling processes in various
compartments of the cell, including the nucleus. To gain further insight into the functions of …

Die Herzinsuffizienz (HI) ist eine der häufigsten und teuersten medizinischen Indikationen in
der heutigen Zeit. rnIn der vorliegenden Arbeit konnte zum ersten Mal die Topoisomerase …

Adult mammalian cardiomyocytes exhibit limited proliferation. Our laboratory has identified
cyclin A2 (CCNA2) as a critical driver of cardiomyocyte proliferation as well as a key repair …