Polyadenylation of pre-messenger RNA (pre-mRNA) specific sites and termination of their
downstream transcriptions are signaled by unique sequence motif structures such as …

Cleavage and polyadenylation of pre-mRNAs is a necessary step for gene expression and
function. Majority of human genes exhibit multiple polyadenylation sites, which can be …

Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative
polyadenylation (APA) to promote cell proliferation and migration. Upregulated CPSF6 leads …

Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3′-UTR
length, resulting in changes in mRNA stability and localization. APA is frequently disrupted …

Many of the cells in mammalian tissues are in a reversible quiescent state; they are not
dividing, but retain the ability to proliferate in response to extracellular signals. Quiescence …

Cleavage of nascent transcripts is a fundamental process for eukaryotic mRNA maturation
and for the production of different mRNA isoforms. In eukaryotes, cleavage of mRNA …

Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an
essential step in co-transcriptional mRNA maturation. Recent work has surprisingly …

Aberrant gene expression lies at the heart of many pathologies. This review will point out
how 3′ end processing, the final mRNA-maturation step in the transcription cycle, is …

Abstract Cleavage factor “CFIm25”, as a key repressor at proximal poly (A) site, negatively
correlates to cell proliferation and tumorigenicity in various cancers. Hence, understanding …

Notch signaling and its downstream gene target HES1 play a critical role in regulating and
maintaining cancer stem cells (CSCs), similar to as they do during embryonic development …