[HTML][HTML] Acute kidney injury: definition, pathophysiology and clinical phenotypes

K Makris, L Spanou - The clinical biochemist reviews, 2016 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the
outcome in a significant number of hospitalised patients. Recent advances in clinical and …

[HTML][HTML] Diabetes and kidney disease: role of oxidative stress

C JhaJay, SM ChowBryna… - Antioxidants & redox …, 2016 - liebertpub.com
Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Relationship between intraoperative hypotension, defined by either reduction from baseline or absolute thresholds, and acute kidney and myocardial injury after …

V Salmasi, K Maheshwari, D Yang, EJ Mascha… - …, 2017 - pubs.asahq.org
Background How best to characterize intraoperative hypotension remains unclear. Thus, the
authors assessed the relationship between myocardial and kidney injury and intraoperative …

[HTML][HTML] Mechanisms and therapeutic targets of ischemic acute kidney injury

SJ Han, HT Lee - Kidney research and clinical practice, 2019 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …

VDAC1 at the intersection of cell metabolism, apoptosis, and diseases

V Shoshan-Barmatz, A Shteinfer-Kuzmine, A Verma - Biomolecules, 2020 - mdpi.com
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

[HTML][HTML] Pathophysiology of acute kidney injury

DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Cellular pathophysiology of ischemic acute kidney injury

JV Bonventre, L Yang - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …

[HTML][HTML] Acute kidney injury and chronic kidney disease: an integrated clinical syndrome

LS Chawla, PL Kimmel - Kidney international, 2012 - Elsevier
The previous conventional wisdom that survivors of acute kidney injury (AKI) tend to do well
and fully recover renal function appears to be flawed. AKI can cause end-stage renal …

Rhabdomyolysis and acute kidney injury

X Bosch, E Poch, JM Grau - New England Journal of Medicine, 2009 - Mass Medical Soc
The causes of acute rhabdomyolysis include trauma, drugs, toxins, and certain infections.
Acute kidney injury is a dangerous complication of severe rhabdomyolysis. This review …

The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

S Chakraborty, S Kaur, S Guha, SK Batra - Biochimica et Biophysica Acta …, 2012 - Elsevier
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …