Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

Cortical folding, or gyrification, coincides with several important developmental processes.
The folded shape of the human brain allows the cerebral cortex, the thin outer layer of …

During human brain development, the cerebral cortex undergoes substantial folding,
leading to its characteristic highly convoluted form. Folding is necessary to accommodate …

Folding of the cerebral cortical surface is a critical process in human brain development, yet
despite decades of indirect study and speculation the mechanics of the process remain …

In humans and many other mammals, the cortex (the outer layer of the brain) folds during
development. The mechanics of folding are not well understood; leading explanations are …

The evolutionary increase in size and complexity of the primate neocortex is thought to
underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene …

As neurons of the developing brain form functional circuits, they undergo morphological
differentiation. In immature cerebral cortex, radially-oriented cellular processes of …

The neocortex is the largest part of the cerebral cortex and a key structure involved in human
behavior and cognition. Comparison of neocortex development across mammals reveals …

There is a basic rule to mammalian neocortical expansion: as it expands, so does it fold. The
degree to which it folds, however, cannot strictly be attributed to its expansion. Across …

Lissencephaly is a rare brain malformation for which our understanding remains limited due
to the absence of suitable animal models that accurately represent human phenotypes …