An improvement in pancreatic cancer treatment represents an urgent medical goal. Late
diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal …

Despite recent advances in molecularly targeted therapies and immunotherapies, the
effective treatment of advanced-stage cancers remains a largely unmet clinical need …

Although traditional chemotherapy kills a fraction of tumor cells, it also activates the stroma
and can promote the growth and survival of residual cancer cells to foster tumor recurrence …

Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors
while current therapeutic approaches show little effect of prolonging the survival of patients …

Breast cancer (BC) is one of the most malignant tumors and the leading cause of cancer-
related death in women worldwide. So, an in-depth investigation on the molecular …

Cancer immunotherapy targeting immune checkpoints has exhibited promising clinical
outcomes in many cancers, but it offers only limited benefits for pancreatic cancer (PC) …

Abstract Background Cancer stem cells (CSCs) are considered responsible for the
recurrence and chemoresistance of cancer. Dysregulated autophagy is highly prevalent in …

Background Endometrial cancer (EC) is one of the female malignant tumors. Endometrial
cancer predominately affects post-menopausal women. Bioinformatics analysis has been …

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the
US. Despite multiple large-scale genetic sequencing studies, identification of predictors of …

Small cell lung cancer (SCLC) is among the most aggressive and lethal human
malignancies. Most patients with SCLC who initially respond to chemotherapy develop …