Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …

Condensins are large protein complexes that play a central role in chromosome
organization and segregation in the three domains of life. They display highly characteristic …

Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby
ensure the successful segregation of replicated genomes. Insights into how condensin …

Condensin is a structural maintenance of chromosomes (SMC) complex family member
thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants …

Cellular proteins do not work in isolation. Instead, they often function as part of large
macromolecular complexes, which are transported and concentrated into specific cellular …

Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape
chromosomes–single molecule in vitro observations have yielded fascinating images of this …

During mitosis, the condensin I and II complexes compact chromatin into chromosomes.
Loss of the chromokinesin, KIF4A, results in reduced condensin I association with …

The condensin protein complex plays a key role in the structural organization of genomes.
How the ATPase activity of its SMC subunits drives large-scale changes in chromosome …