As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

Despite daily fasting and feeding, plasma glucose levels are normally maintained within a
narrow range owing to the hormones insulin and glucagon. Insulin increases glucose …

Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …

GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated
glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in …

Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

Rab proteins are important regulators of insulin-stimulated GLUT4 translocation to the
plasma membrane (PM), but the precise steps in GLUT4 trafficking modulated by particular …