The emerging role of HLA‐C in HIV‐1 infection
DA Kulpa, KL Collins - Immunology, 2011 - Wiley Online Library
Recently, genome‐wide association studies have identified the major histocompatibility
complex class I protein HLA‐C as an important molecule that affects HIV disease …
complex class I protein HLA‐C as an important molecule that affects HIV disease …
Identifying and characterizing recently transmitted viruses
BF Keele - Current Opinion in HIV and AIDS, 2010 - journals.lww.com
Acute HIV infection is a critical window of opportunity for vaccine and therapeutic
intervention. New sequencing technologies and mathematical modeling of transmission and …
intervention. New sequencing technologies and mathematical modeling of transmission and …
The HIV-1 latent reservoir is largely sensitive to circulating T cells
HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral
variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus …
variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus …
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
Given that HIV evolution and latent reservoir establishment occur continually within-host,
and that latently infected cells can persist long-term, the HIV reservoir should comprise a …
and that latently infected cells can persist long-term, the HIV reservoir should comprise a …
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The
role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 …
role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 …
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C
JK Wright, V Novitsky, MA Brockman… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT HLA class I-mediated selection of immune escape mutations in functionally
important Gag epitopes may partly explain slower disease progression in HIV-1-infected …
important Gag epitopes may partly explain slower disease progression in HIV-1-infected …
HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the “test-and-treat” approach to reduce HIV transmission
The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C
infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in …
infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in …
Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships
J Tang, R Malhotra, W Song, I Brill, L Hu, PK Farmer… - PloS one, 2010 - journals.plos.org
Background During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively
stable quantitative trait that has clinical and epidemiological implications. Immunogenetic …
stable quantitative trait that has clinical and epidemiological implications. Immunogenetic …
Transmission of single and multiple viral variants in primary HIV-1 subtype C infection
V Novitsky, R Wang, L Margolin, J Baca… - PLoS …, 2011 - journals.plos.org
To address whether sequences of viral gag and env quasispecies collected during the early
post-acute period can be utilized to determine multiplicity of transmitted HIV's, recently …
post-acute period can be utilized to determine multiplicity of transmitted HIV's, recently …
[HTML][HTML] Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure
Nef plays a major role in HIV-1 pathogenicity. We studied HIV-1 subtype C infected
individuals in acute/early (n= 120) or chronic (n= 207) infection to investigate the …
individuals in acute/early (n= 120) or chronic (n= 207) infection to investigate the …