Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a
multitude of physiological functions. There is considerable overlap between the affected …

We address the chemical/biological history of H 2 O 2 back at the times of the Archean eon
(2.5–3.9 billion years ago (Gya)). During the Archean eon the pO 2 was million-fold lower …

Molecular level, mechanistic understanding of the roles of reactive oxygen species (ROS) in
a variety of pathological conditions is hindered by the difficulties associated with determining …

The review pinpoints operational concepts related to the redox biology network applied to
the pathophysiology and therapeutics of solid tumors. A sophisticated network of intrinsic …

Abstract Hydrogen peroxide (H 2 O 2) controls signaling pathways in cells by oxidative
modulation of the activity of redox sensitive proteins denominated redox switches. Here …

Exercise redox biochemistry is of considerable interest owing to its translational value in
health and disease. However, unaddressed conceptual, methodological and technical …

Mitochondria are critically important in providing cellular energy ATP as well as their
involvement in anti-oxidant defense, fat oxidation, intermediary metabolism and cell death …

The brain is one of the main organs affected by hypoxia and reoxygenation in the neonatal
period and one of the most vulnerable to oxidative stress. Hypoxia/ischemia and …

Stem cells are believed to maintain a specific intracellular redox status through a
combination of enhanced removal capacity and limited production of ROS. In the present …

Peroxiredoxin (PRDX) is a ubiquitous oxidoreductase protein with a conserved ionised thiol
that permits catalysis of hydrogen peroxide (H 2 O 2) up to a million times faster than any …