The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …

The transcription factor p53 is activated in response to a variety of cellular stresses and
serves as a prominent and potent tumor suppressor. Since its discovery, we have sought to …

Germline and somatic TP53 variants play a crucial role during tumorigenesis. However,
genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ …

Unraveling the molecular nature of skin aging and keratinocyte senescence represents a
challenging research project in epithelial biology. In this regard, depletion of p63, a p53 …

The p53 tumor suppressor protein is best known as an activator of cell cycle arrest and
apoptosis. Only a fraction of p53-activated genes encode proteins affecting cellular …

Breast cancer is the most common cause of death from cancer in women. Here, we present
the case of a 43-year-old woman, who received a diagnosis of claudin-low luminal B breast …

Thioredoxin interacting protein (Txnip) is a stress-responsive factor regulating Trx1 for redox
balance and involved in diverse cellular processes including proliferation, differentiation …

Circadian rhythm disruptions are linked to increased cancer risk and unfavorable prognosis
in patients with cancer, highlighting the critical role of the interplay between the circadian …

Background/aim Ductal carcinoma in situ is considered a local disease with no metastatic
potential, thus sentinel lymph node biopsy (SLNB) may be deemed an overtreatment. SLNB …

诱导多能干细胞(IPSC) 是体细胞重编程后得到的与胚胎干细胞相似的具有自我更新和多向分化
潜能的细胞, 这一发现成功避开了胚胎干细胞的伦理问题. 自IPSC 问世, 这项技术就迅速应用于 …