BK polyomavirus: clinical aspects, immune regulation, and emerging therapies

GR Ambalathingal, RS Francis, MJ Smyth… - Clinical microbiology …, 2017 - Am Soc Microbiol
SUMMARY BK polyomavirus (BKV) causes frequent infections during childhood and
establishes persistent infections within renal tubular cells and the uroepithelium, with …

T cells for viral infections after allogeneic hematopoietic stem cell transplant

CM Bollard, HE Heslop - Blood, The Journal of the American …, 2016 - ashpublications.org
Despite recent advances in the field of allogeneic hematopoietic stem cell transplantation
(HSCT), viral infections are still a major complication during the period of immune …

Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT

A Papadopoulou, U Gerdemann, UL Katari… - Science translational …, 2014 - science.org
It remains difficult to treat the multiplicity of distinct viral infections that afflict
immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe …

Virus-specific T-cell banks for'off the shelf'adoptive therapy of refractory infections

RJ O'Reilly, S Prockop, AN Hasan, G Koehne… - Bone marrow …, 2016 - nature.com
Adoptive immunotherapy with transplant donor-derived virus-specific T cells has emerged
as a potentially curative approach for the treatment of drug-refractory EBV+ lymphomas as …

Virus-specific T cells for the immunocompromised patient

A Houghtelin, CM Bollard - Frontiers in immunology, 2017 - frontiersin.org
While progress has been made in the treatment of both hematologic cancers and solid
tumors, chemorefractory or relapsed disease often portends a dismal prognosis, and …

The generation and application of antigen-specific T cell therapies for cancer and viral-associated disease

AB Hont, AB Powell, DK Sohai, IK Valdez… - Molecular Therapy, 2022 - cell.com
Immunotherapy with antigen-specific T cells is a promising, targeted therapeutic option for
patients with cancer as well as for immunocompromised patients with virus infections. In this …

[HTML][HTML] The loss of BKV-specific immunity from pretransplantation to posttransplantation identifies kidney transplant recipients at increased risk of BKV replication

T Schachtner, M Stein, N Babel, P Reinke - American Journal of …, 2015 - Elsevier
Quantification of BKV-load and BKV-specific immunity have been evaluated to monitor BKV-
replication and outcomes in kidney transplant recipients (KTRs) with BKV-infection …

Prophylactic antigen‐specific T‐cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant

DJ Gottlieb, LE Clancy, B Withers… - Clinical & …, 2021 - Wiley Online Library
Objectives Adoptive immunotherapy using donor‐derived antigen‐specific T‐cells can
prevent and treat infection after allogeneic haemopoietic stem cell transplant (HSCT) …

BK polyomavirus and the transplanted kidney: immunopathology and therapeutic approaches

C Lamarche, J Orio, S Collette, L Senécal… - …, 2016 - journals.lww.com
BK polyomavirus is ubiquitous, with a seropositivity rate of over 75% in the adult population.
Primary infection is thought to occur in the respiratory tract, but asymptomatic BK virus …

Adoptive T cell therapy strategies for viral infections in patients receiving haematopoietic stem cell transplantation

G Ottaviano, R Chiesa, T Feuchtinger, MA Vickers… - Cells, 2019 - mdpi.com
Adverse outcomes following virus-associated disease in patients receiving allogeneic
haematopoietic stem cell transplantation (HSCT) have encouraged strategies to control viral …