Dyspnea is a distressing, debilitating, and near-ubiquitous symptom affecting patients with
COPD. In addition to the functional consequences of dyspnea, which include activity …

Multiple frontal cortical brain regions have emerged as being important in pain processing,
whether it be integrative, sensory, cognitive, or emotional. One such region, Brodmann Area …

The periaqueductal gray (PAG) plays a critical role in autonomic function and behavioural
responses to threatening stimuli. Recent evidence has revealed the PAG's potential …

The sensation that develops as a long breath hold continues is what this article is about. We
term this sensation of an urge to breathe 'air hunger'. Air hunger, a primal sensation, alerts …

Dyspnea refers to the sensation of breathlessness, shortness of breath, or difficulty breathing
that is commonly observed in patients with respiratory and cardiac disease. In the United …

Breathing is peculiar among autonomic functions through several characteristics. It
generates a very rich afferent traffic from an array of structures belonging to the respiratory …

This statement outlines a review of the literature and current practice concerning the
prevalence, clinical significance, diagnosis and management of dyspnoea in critically ill …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterized by progressive diaphragm weakness and deteriorating lung function. Bulbar …

A person's expectations and mood are major contributors to the function of the brain
networks that generate perceptions of breathlessness. Breathlessness, therefore, arises …

Previously we observed differential activation in individual columns of the periaqueductal
grey (PAG) during breathlessness and its conditioned anticipation. Here, we have extended …