Exploring the synthesis, properties, and potential of chitosan-functionalized metal-organic frameworks in emerging applications

A Sathiyaseelan, X Zhang, Y Lu, NA l Azeez… - Progress in Materials …, 2024 - Elsevier
Chitosan (CS), a natural cationic biopolymer, has emerged as a promising component for
synthesizing biological/bioinspired metal–organic frameworks (BioMOFs). CS's abundant …

Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2024 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies

N Yasser, FM Sroor, HM El-Shorbagy, SM Eissa… - RSC …, 2024 - pubs.rsc.org
A unique series of pyrazolyl-chalcone derivatives was synthesized via the method of Claisen–
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …

One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium

S Suresh, FR Nawaz Khan - ACS omega, 2024 - ACS Publications
The sequential synthesis of N-heterocycles from saturated ketones poses significant
challenges and has rarely been reported. Herein, an efficient synthesis of alkenylated …

Recent developments on microwave-assisted organic synthesis of nitrogen-and oxygen-containing preferred heterocyclic scaffolds

G Tiwari, A Khanna, VK Mishra, R Sagar - RSC advances, 2023 - pubs.rsc.org
In recent decades, the utilization of microwave energy has experienced an extraordinary
surge, leading to the introduction of innovative and revolutionary applications across various …

Structural and theoretical exploration of a multi-methoxy chalcone: Synthesis, quantum theory, electrostatics, molecular packing, DFT analysis, and in-silico anti …

FH Al-Ostoot, P Akhileshwari, VH Kameshwar… - Heliyon, 2024 - cell.com
This study explores the pharmacological potential of chalcones through a multidisciplinary
approach, including synthesis, quantum theory, molecular electrostatics, and density …

Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA …

MG Kamel, FM Sroor, MKH Hanafy, KF Mahrous… - RSC …, 2024 - pubs.rsc.org
Less than 5% of pancreatic cancer patients survive for more than five years after diagnosis.
Therefore, there is an urgent need for novel therapeutic drugs to treat pancreatic cancer …

“On-water” synthesis of thioxoimidazolidinone-isatin/ninhydrin conjugates, followed by temperature-induced dehydration by a ZnMnO 3@ Ni (OH) 2 nano-catalyst

S Rana, S Basu, A Bera, P Saha, P Ghosh… - Green …, 2024 - pubs.rsc.org
A novel and efficient “on water” mediated one-pot ZnMnO3@ Ni (OH) 2 catalyzed straight-
forward synthesis of 3-hydroxy-3-(3-methyl-5-oxo-2-thioxoimidazolidin-4-yl) oxindole via a …

[HTML][HTML] Synthesis of new thiazole-privileged chalcones as tubulin polymerization inhibitors with potential anticancer activities

H Hashem, A Hassan, WM Abdelmagid… - …, 2024 - pmc.ncbi.nlm.nih.gov
A series of novel thiazole-based chalcones were evaluated for their anticancer activity as
potential tubulin polymerization inhibitors. In vitro anticancer screening for the thiazole …

Synthesis and In vitro evaluation of bichalcones as novel anti-toxoplasma agents

F Mazzone, MKT Klischan, J Greb, SHJ Smits… - Frontiers in …, 2024 - frontiersin.org
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an apicomplexan
parasite that infects approximately a third of the world's human population. This disease can …