Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP) are
chronic respiratory diseases. These two disorders often co-exist based on common …

Five biological drugs are currently marketed for treatment of uncontrolled severe asthma.
They all block type 2 inflammatory pathways by targeting IgE (omalizumab), the IL-5 …

Eosinophils are specialized white blood cells, which are involved in the pathology of diverse
allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as …

Chronic rhinosinusitis (CRS) is a persistent inflammation of the nasal cavity and paranasal
sinuses associated with tissue remodelling, dysfunction of the sinuses' natural defence …

Eosinophils are circulating granulocytes that have pleiotropic effects in response to
inflammatory signals in the body. In response to allergens or pathogens, exposure …

Background Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are
proteins released by activated eosinophils whose role in adult asthma remains unclear …

Allergic rhinitis is a highly prevalent chronic inflammatory disorder of the nasal mucosa that
poses a significant burden on patients' health and quality of life. Current therapies for …

The ability of human tissue to reorganize and restore its existing structure underlies tissue
homeostasis in the healthy airways, but in disease can persist without normal resolution …

Chronic rhinosinusitis (CRS) with or without nasal polyposis is a complex medical condition
characterized by varying patterns of chronic innate and adaptive mucosal inflammation …