Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Poloxamer: A versatile tri-block copolymer for biomedical applications

P Zarrintaj, JD Ramsey, A Samadi, Z Atoufi, MK Yazdi… - Acta biomaterialia, 2020 - Elsevier
Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers
containing central hydrophobic chains of poly (propylene oxide) sandwiched between two …

New advances in biomedical application of polymeric micelles

A Figueiras, C Domingues, I Jarak, AI Santos, A Parra… - Pharmaceutics, 2022 - mdpi.com
In the last decade, nanomedicine has arisen as an emergent area of medicine, which
studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility …

Liposomal drug delivery systems for the treatment of leishmaniasis

FF Tuon, LR Dantas, RM de Souza, VST Ribeiro… - Parasitology …, 2022 - Springer
Human le ishmaniasis is a vector-borne, neglected infectious disease that is widely
distributed in America, Africa, Europe, and Asia. Current therapy is based on old and toxic …

A topical gel nanoformulation of amphotericin B (AmB) for the treatment of cutaneous leishmaniasis (CL)

R Boshrouyeh, S Amari… - Journal of Sol-Gel …, 2023 - Springer
This study aimed to improve the water solubility and cutaneous permeability of Amphotericin
B (AmB) for the topical treatment of Leishmania major-induced cutaneous leishmaniasis …

[HTML][HTML] Advances and challenges in nanocarriers and nanomedicines for veterinary application

SG Carvalho, VHS Araujo, AM Dos Santos… - International journal of …, 2020 - Elsevier
To ensure success in the development and manufacturing of nanomedicines requires forces
of an interdisciplinary team that combines medicine, engineering, chemistry, biology …

Triblock copolymeric drug delivery as an emerging nanocarrier for treatment of infectious diseases

V Singh, K Eljaaly, S Md, NA Alhakamy… - Journal of Drug Delivery …, 2022 - Elsevier
Polymers have long been employed as carriers of choice for efficient delivery of therapeutic
agents. Several block copolymers including triblock copolymers have been designed using …

[HTML][HTML] A clioquinol-containing Pluronic® F127 polymeric micelle system is effective in the treatment of visceral leishmaniasis in a murine model

GSV Tavares, DVC Mendonça, IAG Pereira… - Parasite, 2020 - ncbi.nlm.nih.gov
A clioquinol (ICHQ)-containing Pluronic® F127 polymeric micelle system (ICHQ/Mic) was
recently shown to be effective against Leishmania amazonensis infection in a murine model …

Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases

MA Toscanini, MJ Limeres, AV Garrido, M Cagel… - Journal of Drug Delivery …, 2021 - Elsevier
Despite all the advances in understanding the pathogenesis of infectious diseases and the
development of novel treatments to combat them, these pathogenic disorders are among the …

Exploring drug repositioning for leishmaniasis treatment: Ivermectin plus polymeric micelles induce immunological response and protection against tegumentary …

CS Freitas, DP Lage, AS Machado, DL Vale… - Cytokine, 2023 - Elsevier
Leishmania amazonensis can cause a wide spectrum of the clinical manifestations of
leishmaniasis in humans. The development of new therapeutics is a long and expensive …