Acute kidney injury (AKI) and chronic kidney disease (CKD) are significant public health
issues associated with a long-term increase in mortality risk, resulting from various etiologies …

In angiotensin II (Ang II)-dependent hypertension, Ang II activates angiotensin II type 1
receptors (AT1R) on renal vascular smooth muscle cells, leading to renal vasoconstriction …

Background Hypertensive nephropathy (HN) is one of the main causes of end-stage renal
disease (ESRD), leading to serious morbidity and mortality in hypertensive patients …

Degenerative diseases, encompassing a wide range of conditions affecting various organ
systems, pose significant challenges to global healthcare systems. This comprehensive …

Hypertensive nephropathy continues to be a major cause of end-stage renal disease and
poses a significant global health burden. Despite the staggering development of research in …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the
ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the …

Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are
of paramount importance for intercellular communication. In physiological conditions, HCs …

DUX4 is typically a repressed transcription factor, but its aberrant activation in
Facioscapulohumeral Muscular Dystrophy (FSHD) leads to cell death by disrupting muscle …

Chronic kidney disease (CKD) is a prevalent health concern associated with various
pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in …

Objective Hypertension is one of the main causes of chronic kidney disease. Astragalus
membranaceus (AM), an important traditional Chinese medicine for treating hypertensive …