Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …

In the present study, we have designed imidazo [2, 1-b] thiazole and benzo [d] imidazo [2, 1-
b] thiazole derivatives from earlier reported imidazo [1, 2-a] pyridine based Mycobacterium …

Despite decades of dedicated research, there remains a dire need for new drugs against
tuberculosis (TB). Current therapies are generations old and problematic. Resistance to …

Abstract The key intermediate 3-aminopyrazolo [4, 3-c] pyridine-4, 6-dione (2) is considered
as a precursor for some novel pyrazolo [4, 3-c] pyridines 4a-c, arylhydrazopyrazolo [4, 3-c] …

A series of benzimidazole derivatives (1–20) was synthesized and evaluated for its in vitro
antimicrobial, antitubercular and anticancer activities. Compound 10 was found to be the …

Tuberculosis (TB), one of the most prevalent infections, is on the rise today. Although there
are drugs available in the market to combat this lethal disorder, there are several …

Based on the molecular hybridization strategy, thirty-four imidazo [1, 2-a] pyridine amides
(IPAs) and imidazo [1, 2-a] pyridine sulfonamides (IPSs) were designed and synthesized …

Background The study describes the synthesis, characterization, in vitro antimicrobial and
anticancer evaluation of a series of 2-(1-benzoyl-1 H-benzo [d] imidazol-2-ylthio)-N …

Highlights•The most recently studied drug targets are reviewed.•The protein–protein
interaction network was generated using STRING database.•Hits and leads were discovered …