The bioinorganic chemistry of mammalian metallothioneins

A Krezel, W Maret - Chemical reviews, 2021 - ACS Publications
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

AIE-based luminescence probes for metal ion detection

P Alam, NLC Leung, J Zhang, RTK Kwok… - Coordination Chemistry …, 2021 - Elsevier
The past two decades have witnessed significant advances in the field of aggregation-
induced emission (AIE). Luminescent materials with AIE characteristics (AIEgens) are of …

Zinc as a gatekeeper of immune function

I Wessels, M Maywald, L Rink - Nutrients, 2017 - mdpi.com
After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential
for the function of the immune system. Zinc ions are involved in regulating intracellular …

Zinc in infection and inflammation

NZ Gammoh, L Rink - Nutrients, 2017 - mdpi.com
Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an
essential micronutrient that is involved in the regulation of the innate and adaptive immune …

Dietary and physiological effects of zinc on the immune system

I Wessels, HJ Fischer, L Rink - Annual review of nutrition, 2021 - annualreviews.org
Evidence for the importance of zinc for all immune cells and for mounting an efficient and
balanced immune response to various environmental stressors has been accumulating in …

[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Zinc signals and immunity

M Maywald, I Wessels, L Rink - International journal of molecular sciences, 2017 - mdpi.com
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency
as well as zinc excess result in severe disturbances in immune cell numbers and activities …

[HTML][HTML] The role of metallothionein in oxidative stress

B Ruttkay-Nedecky, L Nejdl, J Gumulec, O Zitka… - International journal of …, 2013 - mdpi.com
Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …

[HTML][HTML] Zinc biochemistry: from a single zinc enzyme to a key element of life

W Maret - Advances in nutrition, 2013 - Elsevier
The nutritional essentiality of zinc for the growth of living organisms had been recognized
long before zinc biochemistry began with the discovery of zinc in carbonic anhydrase in …

The essential toxin: impact of zinc on human health

LM Plum, L Rink, H Haase - … journal of environmental research and public …, 2010 - mdpi.com
Compared to several other metal ions with similar chemical properties, zinc is relatively
harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a …