Pre-eclampsia

E Dimitriadis, DL Rolnik, W Zhou… - Nature reviews Disease …, 2023 - nature.com
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis

F Louwen, NN Kreis, A Ritter, A Friemel… - Human …, 2022 - academic.oup.com
BACKGROUND The key oncogene B-cell lymphoma 6 (BCL6) drives malignant progression
by promoting proliferation, overriding DNA damage checkpoints and blocking cell terminal …

A real-world multi-center RNA-seq benchmarking study using the Quartet and MAQC reference materials

D Wang, Y Liu, Y Zhang, Q Chen, Y Han, W Hou… - Nature …, 2024 - nature.com
Translating RNA-seq into clinical diagnostics requires ensuring the reliability and cross-
laboratory consistency of detecting clinically relevant subtle differential expressions, such as …

Placentas from Women with Late-Onset Preeclampsia Exhibit Increased Expression of the NLRP3 Inflammasome Machinery

LM Garcia-Puente, O Fraile-Martinez… - Biomolecules, 2023 - mdpi.com
Pre-eclampsia is a harmful and potentially lethal medical condition during pregnancy
clinically diagnosed by hypertension and commonly accompanied by proteinuria and …

Potential biomarkers for late-onset and term preeclampsia: A scoping review

L Han, OJ Holland, F Da Silva Costa… - Frontiers in …, 2023 - frontiersin.org
Preeclampsia is a progressive, multisystem pregnancy disorder. According to the time of
onset or delivery, preeclampsia has been subclassified into early-onset (< 34 weeks) and …

Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells

R Hunter, B Baird, M Garcia, J Begay… - Toxicological …, 2023 - academic.oup.com
Ozone (O3) is a criteria air pollutant with the most frequent incidence of exceeding air quality
standards. Inhalation of O3 is known to cause lung inflammation and consequent systemic …

Expression profiles and functions of ferroptosis-related genes in the placental tissue samples of early-and late-onset preeclampsia patients

N Yang, Q Wang, B Ding, Y Gong, Y Wu, J Sun… - BMC Pregnancy and …, 2022 - Springer
Background The accumulation of reactive oxygen species (ROS) resulting from upregulated
levels of oxidative stress is commonly implicated in preeclampsia (PE). Ferroptosis is a …

Reliability of rodent and rabbit models in preeclampsia research

A Sakowicz, M Bralewska, P Kamola… - International Journal of …, 2022 - mdpi.com
In vivo studies on the pathology of gestation, including preeclampsia, often use small
mammals such as rabbits or rodents, ie, mice, rats, hamsters, and guinea pigs. The key …

H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia

J Deng, HJ Zhao, Y Zhong, C Hu, J Meng, C Wang… - …, 2023 - thelancet.com
Background Preeclampsia (PE) is a common hypertensive pregnancy disorder associated
with shallow trophoblast invasion. Although bone morphogenetic protein 2 (BMP2) has been …

[HTML][HTML] The mechanism of action of non-coding RNAs in placental disorders

S Kannampuzha, M Ravichandran… - Biomedicine & …, 2022 - Elsevier
Placental complication arises due to various risk factors occurring during the pregnancy
period, leading to an increased morbidity rate. Placenta related disorders are one of primary …