The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

The rhodopsin crystal structure provides a structural basis for understanding the function of
this and other G protein–coupled receptors (GPCRs). The major structural motifs observed …

Following exposure of our eye to very intense illumination, we experience a greatly elevated
visual threshold, that takes tens of minutes to return completely to normal. The slowness of …

Rim protein (RmP) is an ABC transporter of unknown function in rod outer segment discs.
The human gene for RmP (ABCR) is affected in several recessive retinal degenerations …

We have determined the structure of bovine rhodopsin at 2.65 Å resolution using untwinned
native crystals in the space group P31, by molecular replacement from the 2.8 Å model …

G protein-coupled receptors (GPCRs) are ubiquitous signal transducers in cell membranes,
as well as important drug targets. Interaction with extracellular agonists turns the seven …

When light is absorbed within the outer segment of a vertebrate photoreceptor, the
conformation of the photopigment rhodopsin is altered to produce an activated photoproduct …

Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented
epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal …

This article is divided into two sections. The first outlines the molecular events that underlie
the onset of phototransduction, the photoreceptor's response to light, and provides a …

The second edition of this best-selling handbook is bigger, more comprehensive, and now
completely current. In addition to thorough updates to the discussions featured in the first …