Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …

Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …

HLA‐G is considered as an immune checkpoint protein and a tumor‐associated antigen. In
the previous work, it is reported that CAR‐NK targeting of HLA‐G can be used to treat certain …

Dear Editor, Tonic signaling of chimeric antigen receptors (CARs) plays a pivotal role in
governing CAR-T cell fitness: inefficient tonic signaling results in poor CAR-T persistence …

Simple Summary Cancer accounts for an increasing number of deaths year on year.
However, new immune-based therapies offer promise in the quest to address this unmet …

Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar
yet also different manifestations at the histological, cellular, and clinical levels …

The development of recombinant antibody fragments as promising alternatives to full-length
immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have …

Different from surgery, chemical therapy, radio-therapy and target therapy, Chimeric antigen
receptor-modified T (CAR-T) cells, a novel adoptive immunotherapy strategy, have been …

Antibodies represent a relatively mature detection means and serve as therapeutic drug
carriers in the clinical diagnosis and treatment of cancer—among which monoclonal …

Conclusion: Our findings indicate that altering the hinge and transmembrane domains of a
nanobody-based CAR targeting a distal GPC3 epitope, in contrast to a membrane proximal …