From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger
RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

microRNAs (miRNAs) are widespread among eukaryotes, and studies in several systems
have revealed that miRNAs can regulate expression of specific genes. Primary miRNA …

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

The anchor-away (AA) technique depletes the nucleus of Saccharomyces cerevisiae of a
protein of interest (the target) by conditional tethering to an abundant cytoplasmic protein …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Gene expression in eukaryotes requires several multi-component cellular machines. Each
machine carries out a separate step in the gene expression pathway, which includes …

TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …