Since the publication of the guidelines for the assessment and management of non alcoholic
fatty liver disease (NAFLD) by the Asia–Pacific Working Party on NAFLD in 2007, 1 our …

Milk thistle (Silybum marianum) is a medicinal plant from the Asteraceae family. Silymarin is
the major constituent of milk thistle extract and is a mixture of some flavonolignans such as …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance.
Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative …

Background & Aims Silymarin is a complex mixture of 6 major flavonolignans and other
minor polyphenolic compounds derived from the milk thistle plant Silybum marianum; it has …

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285
million people worldwide and results in heavy personal and national economic burdens …

How to assess efficacy of interventions. In clinical practice, and particularly among those
who appear to have mild liver disease, it may be sufficient to note changes (normalization) of …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …

Metabolic syndrome describes a complex metabolic risk factors including obesity,
hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical …

Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …