Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

Protein function is often regulated by posttranslational modifications (PTMs), and recent
advances in mass spectrometry have resulted in an exponential increase in PTM …

Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the
regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative …

The yeast SAGA (Spt–Ada–Gcn5–acetyltransferase) coactivator complex exerts functions in
gene expression, including activator interaction, histone acetylation, histone …

Reversible posttranslational modification of internal lysines in many cellular or viral proteins
is now emerging as part of critical signalling processes controlling a variety of cellular …

Pathological cardiac hypertrophy is a process of abnormal remodeling of cardiomyocytes in
response to pressure overload or other stress stimuli, resulting in myocardial injury, which is …

Lysine acetylation is a widespread post-translational modification regulating various
biological processes. To characterize cellular functions of the human lysine …

Cellular and biochemical studies support a role for all five human RecQ helicases in DNA
replication; however, their specific functions during this process are unclear. Here we …

Lysine acetylation is a post-translational modification that regulates gene transcription by
targeting histones as well as a variety of transcription factors in the nucleus. Recently …