Amyloid plaques beyond Aβ: a survey of the diverse modulators of amyloid aggregation

KL Stewart, SE Radford - Biophysical reviews, 2017 - Springer
Aggregation of the amyloid-β (Aβ) peptide is strongly correlated with Alzheimer's disease
(AD). Recent research has improved our understanding of the kinetics of amyloid fibril …

Functional reciprocity of amyloids and antimicrobial peptides: Rethinking the role of supramolecular assembly in host defense, immune activation, and inflammation

EY Lee, Y Srinivasan, J De Anda, LK Nicastro… - Frontiers in …, 2020 - frontiersin.org
Pathological self-assembly is a concept that is classically associated with amyloids, such as
amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease. In prokaryotic …

Extracellular DNA facilitates the formation of functional amyloids in Staphylococcus aureus biofilms

K Schwartz, M Ganesan, DE Payne… - Molecular …, 2016 - Wiley Online Library
Persistent staphylococcal infections often involve surface‐associated communities called
biofilms. S taphylococcus aureus biofilm development is mediated by the co‐ordinated …

New insights in amyloid beta interactions with human telomerase

J Wang, C Zhao, A Zhao, M Li, J Ren… - Journal of the American …, 2015 - ACS Publications
It is well-known that aging is the most risk factor for Alzheimer's disease (AD). Recent studies
have demonstrated that human telomerase is associated with pathological mechanisms of …

Loss of GPNMB causes autosomal-recessive amyloidosis cutis dyschromica in humans

CF Yang, SP Lin, CP Chiang, YH Wu, WS H'ng… - The American Journal of …, 2018 - cell.com
Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis
characterized by generalized hyperpigmentation mottled with small hypopigmented macules …

Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseases

Y Cordeiro, B Macedo, JL Silva, MPB Gomes - Biophysical reviews, 2014 - Springer
Protein misfolding disorders (PMDs) refer to a group of diseases related to the misfolding of
particular proteins that aggregate and deposit in the cells and tissues of humans and other …

The oxidatively damaged DNA and amyloid-β oligomer hypothesis of Alzheimer's disease

OD Sanders, L Rajagopal, JA Rajagopal - Free Radical Biology and …, 2022 - Elsevier
The amyloid-β (Aβ) oligomer hypothesis of Alzheimer's disease (AD) still dominates the field,
yet the clinical trial evidence does not robustly support it. A falsifiable prediction of the …

Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy

R Lathe, JL Darlix - Archives of Virology, 2020 - Springer
The existence of more than 30 strains of transmissible spongiform encephalopathy (TSE)
and the paucity of infectivity of purified PrP Sc, as well as considerations of PrP structure, are …

Modeling genotype–protein interaction and correlation for Alzheimer's disease: a multi-omics imaging genetics study

J Zhang, Z Ma, Y Yang, L Guo, L Du… - Briefings in …, 2024 - academic.oup.com
Integrating and analyzing multiple omics data sets, including genomics, proteomics and
radiomics, can significantly advance researchers' comprehensive understanding of …

Adenosine triphosphate (ATP) reduces amyloid-β protein misfolding in vitro

O Coskuner, IVJ Murray - Journal of Alzheimer's Disease, 2014 - content.iospress.com
Alzheimer's disease (AD) is a devastating disease of aging that initiates decades prior to
clinical manifestation and represents an impending epidemic. Two early features of AD are …