Pathological self-assembly is a concept that is classically associated with amyloids, such as amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease. In prokaryotic …
Persistent staphylococcal infections often involve surface‐associated communities called biofilms. S taphylococcus aureus biofilm development is mediated by the co‐ordinated …
J Wang, C Zhao, A Zhao, M Li, J Ren… - Journal of the American …, 2015 - ACS Publications
It is well-known that aging is the most risk factor for Alzheimer's disease (AD). Recent studies have demonstrated that human telomerase is associated with pathological mechanisms of …
CF Yang, SP Lin, CP Chiang, YH Wu, WS H'ng… - The American Journal of …, 2018 - cell.com
Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottled with small hypopigmented macules …
Protein misfolding disorders (PMDs) refer to a group of diseases related to the misfolding of particular proteins that aggregate and deposit in the cells and tissues of humans and other …
OD Sanders, L Rajagopal, JA Rajagopal - Free Radical Biology and …, 2022 - Elsevier
The amyloid-β (Aβ) oligomer hypothesis of Alzheimer's disease (AD) still dominates the field, yet the clinical trial evidence does not robustly support it. A falsifiable prediction of the …
R Lathe, JL Darlix - Archives of Virology, 2020 - Springer
The existence of more than 30 strains of transmissible spongiform encephalopathy (TSE) and the paucity of infectivity of purified PrP Sc, as well as considerations of PrP structure, are …
J Zhang, Z Ma, Y Yang, L Guo, L Du… - Briefings in …, 2024 - academic.oup.com
Integrating and analyzing multiple omics data sets, including genomics, proteomics and radiomics, can significantly advance researchers' comprehensive understanding of …
O Coskuner, IVJ Murray - Journal of Alzheimer's Disease, 2014 - content.iospress.com
Alzheimer's disease (AD) is a devastating disease of aging that initiates decades prior to clinical manifestation and represents an impending epidemic. Two early features of AD are …