Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such
as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect …

Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

Autophagy and inflammation are 2 fundamental biological processes involved in both
physiological and pathological conditions. Through its crucial role in maintaining cellular …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades
cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is a major …

Autophagy is a complicated cellular mechanism that maintains cellular and tissue
homeostasis and integrity via degradation of senescent, defective subcellular organelles …